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Monoclonal Antibody ICSM 3 Product No. 0130-00301 100µg monoclonal anti-PrP ICSM 3 Product No. 0130-00310 1mg monoclonal anti-PrP ICSM 3 Product description Monoclonal anti- prion protein (PrP); purified mouse immunoglobulin The antibody isotype is IgG1κ Concentration 1mg/ml in 0.1M Tris/Glycine, pH 7.0, >95% pure. The antibody is sterile filtered and contains 10mM sodium azide as preservative. Note: Purified antibodies can be supplied without sodium azide preservative on request at the same price. When placing your order please make sure to inform us of your specific request by filling in the comments and special instructions box (for online orders) or email us at sales@d-gen.co.uk Specificity ICSM 3 specifically reacts with human native and denatured PrPC and denatured PrPSc. The antibody also reacts with sheep, mouse, hamster and bovine PrP. By western blotting and immunoprecipitation ICSM 3 does not bind to diglycosylated PrP; binding only unglycosylated PrP and a subset of mono-glycosylated PrP. The mono-glycosylated PrP detected by ICSM 3 has a lower relative molecular mass than detected by ICSM 10 (Beringue et al., 2003 for mouse PrP, human unpublished data). The antibody epitope is not defined. Storage and Stability This product may be stored at 0-5°C for continuous or daily use. For long term storage the antibody can be frozen in aliquots at -20°C. Repeated freeze-thawing should be avoided. Applications ICSM 3 can be used for detection of PrP by immunoprecipitation, western blotting, FACS and immunohistochemistry. (WB >1mg/ml, IP & FACS 10mg/ml, the antibody has not been titrated to give a minimum working concentration). Research Use Only This product is for Research Use Only and must not be used for diagnostic, therapeutic or manufacturing purposes. Health, Safety and Waste All users of this product must ensure that: (i) this product's specification is safe for their intended use (ii) the product is handled in a safe manner using good laboratory practice and in accordance with any relevant local or national regulations pertaining to the use of such products; and (iii) any waste originating from the product or its use is disposed of in accordance with any relevant local or national regulations.
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